Comparison of the degree of collectivity of motions amongst proteins in a dataset
Issue #867
new
In connection to the above, I'd be grateful for any guidance/suggestions regarding the following:
- Is cross-correlation or GeoStaS analysis appropriate to compare the degree of domain motions? If yes, will the slowest 10 modes suffice for the analysis? From this type of analysis is there a way of identifying those proteins in the dataset with the highest collectivity of motions?
- Is deformation analysis suitable for the purpose? If yes, is deformation analysis using the first non-trivial mode adequate for the purpose? Hollup, S.M., G. Salensminde, and N. Reuter, WEBnm@: a web application for normal mode analyses of proteins. BMC Bioinformatics, 2005. 6: p. 52.
- Any other appropriate methods?
Thank you in advance and best wishes for 2022