Model input often have to be estimated from experimental data as well. For a statistically sound description of the model the input signals should be comprehensively estimated with the model dynamics.
- Schelker M., et al. Comprehensive estimation of input signals and dynamical parameters in biochemical reaction networks. Bioinformatics 28(18), i522-i528, 2012.
One example of modeling an input using cubic splines is shown in the example application JAK/STAT signaling model.