If I load more than a few plugins, Playtime becomes unusable. Every go around of an audio loop, there is an ugly crackle and audio skip (the same sound that happens when the buffer size on an audio interface is too low). This skip becomes worse every iteration of the loop, and sometimes, after a few minutes of the loop, audio playback will completely stall. I have tried all sorts of buffer settings in Reaper preferences, to no avail. I've tried increasing the buffer size to +6000ms and I've tried disabling buffering altogether. I've disabled/enabled Anticipate FX processing, etc. I've toggled the disable media buffering and FX settings in Playtime. Even when I increase my audio interface buffer size to a ridiculous 2048, the lag/distortion still occurs, with no improvement.
I am able to run projects 10x more complicated in Ableton with no hiccups. (I really, really want to ditch Ableton and move my entire producing/mixing process to Reaper.) When mixing a normal Reaper project I can load many high-memory Kontakt instruments and CPU-intensive plugins with no problem.
It is as if the audio files are not loaded into memory and need to be reloaded every loop repeat, regardless of buffer settings.
I attached the project and audio files, but I'm not sure how helpful it will be without all the same plugins...
UMC404HD (issue also occurs with my Mackie Onyx Blackjack)
16 gb ram
i7 @ 2.20 GHz
Various LePou guitar amp sims, Ignite Amps NadIR cabinet sim, and Sitalia drum machine--happens regardless of what combo of VSTs and VSTis I load.