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Corre, a co-methylation browser

Epigenetic alterations are a widespread signature of human cancer, including
generalized changes in DNA methylation status and variability. Whilst frequently
affecting small to large regions of co-localized CpGs (i.e. CpG island shores),
non adjacent loci also co-methylate.

To get insight into this phenomenon we have developed Corre, a browser
of co-methylations in colon cancer.

Corre is in part based upon data generated by the TCGA Research Network:
http://cancergenome.nih.gov/ and Colonomics http://colonomics.org.

Colonomics series included primary tumors and their adjacent normal tissue from
microsatellite-stable samples at stage II (82 at IIA and 8 at IIB) from patients,
67 males and 23 females, aged 43-86 years (mean 70.37); 20 developed metastasis.

The Cancer Genome Atlas (TCGA) series was composed by 256 primary tumor and
38 adjacent normal samples from the colon adenocarcinoma (COAD) cohort from
patients aged 31 to 90 years at diagnosis (mean 65.61), being 141 males,
144 females and one unassigned. Pathologic stages included Stage I (40),
Stage II (97), Stage III (75), Stage IV (32); 11 were not available or discrepant.
Regarding microsatellite instability, 10 were positive, 65 negative and 181 were
either not tested or had an unknown status.

izaskun.mallona@gmail.com
mpeinado@igtp.cat