Design matrix selection
Issue #132
resolved
Hello,
I am trying to using mixOmics to integrate transcriptomics and metabolomics data. How would one decide on the appropriate design matrix to input for the block.splsda function. I see there is posting in the FAQ section under the mixOmics site http://mixomics.org/faq/data-input/.
Does that mean i have to run spls function to figure out the correlation structure between the two datasets and use that value in creating a design matrix.
Thanks for any one making suggestions.
-Raj
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Hi Rajanikanth,
This question is discussed in the Diablo paper (on bioarxiv: https://www.biorxiv.org/content/early/2018/03/20/067611).
You can either do pairwise analysis with pls and fill the design matrix with the correlation, or you can also use a full model (by default).