Need to validate the significance tests in testDiversity

Issue #11 new
Jason Vander Heiden created an issue

Does low sequence counts and/or low clone size (low clone size variance) lead to inflated significance scores from testDiversity()? This needs to be tested and corrected if that's the case.

Comments (2)

  1. Jason Vander Heiden reporter

    Swapped this for the Chao et al, 2014 bootstrap from inferred complete abundance distribution. This should resolve the inflation, but it still needs to be tested.

  2. Jason Vander Heiden reporter

    Low sequence counts (<1000) may still be a problem. We might need to redo the inference of the complete clonal abundance distribution with each bootstrap realization or something.

  3. Log in to comment