changeo /

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Added tag Version 0.4.5 for changeset 0462944b6395
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1. IgPhyML doc updates.
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Updated license to CC BY-SA 4.0.
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Updated news.
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Bump requirements to presto v0.5.9 and enable pipelines.
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1. IgPhyML doc updates.
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1. Re-enable BuildTrees installation and docs.

Change-O - Repertoire clonal assignment toolkit

Change-O is a collection of tools for processing the output of V(D)J alignment tools, assigning clonal clusters to immunoglobulin (Ig) sequences, and reconstructing germline sequences.

Dramatic improvements in high-throughput sequencing technologies now enable large-scale characterization of Ig repertoires, defined as the collection of trans-membrane antigen-receptor proteins located on the surface of B cells and T cells. Change-O is a suite of utilities to facilitate advanced analysis of Ig and TCR sequences following germline segment assignment. Change-O handles output from IMGT/HighV-QUEST and IgBLAST, and provides a wide variety of clustering methods for assigning clonal groups to Ig sequences. Record sorting, grouping, and various database manipulation operations are also included.