Neuropeptides - an overview | ScienceDirect Topics
    Neuropeptides are considered key mediators in the communication between neurons (in particular sensory neurons) and effector cells (smooth muscle, glands, and immune cells) and exhibit a variety of functions in the gastrointestinal tract. Neuropeptides are involved in the secretion of salivary, gastric fluids and intestinal fluids and electrolytes, and G protein-coupled receptors (GPCRs) that bind neuropeptides represent potentially useful peptide therapeutics.
    Gastrointestinal Peptide Binding and Function in the Brain ...
    These factors affect various body functions, including cardiovascular, respiratory, gastrointestinal, endocrine and central nervous system (CNS) functions. Neuropeptide research thus has become one of the most rapidly growing areas of neuroscience.
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    GRAPHICS. Synthesis — Enteroendocrine cells producing gastrointestinal (GI) peptides are dispersed throughout the GI tract. However, specific types of cells demonstrate regional specificity ( table 2) [ 3 ]. This specificity may be related to the physiologic action of the peptide and receptor location. All GI peptides are synthesized via gene
    Remote control of renal physiology ... - PubMed Central (PMC)
    Besides the CNS and digestive tract, no PDF immunoreactivity was apparent in other adult tissues. Absence of innervation of the renal tubules (Fig. 1I) was further confirmed using transmission electron microscopy (Fig. 1C and Fig. S1). Thus, the only visceral site of PDF innervation is the posterior intestine, which is supplied by the central neurosecretory MP1 and dMP2 lineages.
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    Neuropeptide Y (NPY) is a principal neurotransmitter found in the central and peripheral nervous systems and is predominantly found in sympathetic neurons . Peptide YY (PYY) has been localized to enteroendocrine cells in the mucosa of the gastrointestinal tract and is most highly concentrated in the ileum and colon . PYY is produced by two different cell types within the intestine, namely, L cells where it is colocalized with enteroglucagon and H cells of the colon and rectum.
    Neuropeptide S Receptor Induces Neuropeptide Expression ...
    Although their induction remains to be verified in the intestinal enteroendocrine cell type(s) expressing the receptor, many of these and other peptides and hormones up-regulated by NPS (such as substance P, neurotensin and the alpha subunit of chorionic gonadotropin, LH, FSH and TSH, ) are involved in the control of physiological motor and sensory functions in the gastrointestinal tract.