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wbprocesses(google site)

process model

Proposed structure for the WB biological processes model

?WBProcess	Name  ?Text
		Summary ?Text #Evidence
		Process_term ?Text
		Other_name ?Text
		Related_process ?WBProcess XREF Related_process
		Taxon	NCBITaxonomyID ?Text
		Involved_entity		Gene ?Gene XREF WBProcess #Evidence  
					Expression_cluster ?Expression_cluster XREF WBProcess  #Evidence
					Interaction ?Interaction XREF WBProcess #Evidence
					Anatomy_term ?Anatomy_term XREF WBProcess #Evidence
					Life_stage ?Life_stage XREF WBProcess #Evidence 
                                        Molecule ?Molecule XREF WBProcess #Evidence 
		Associated_with		Phenotype ?Phenotype XREF WBProcess #Evidence
  					GO_term ?GO_term  #Evidence
		Picture ?Picture #Evidence
		Movie ?Movie  #Evidence
		Pathway DB_info Database ?Database_field ?Accession_number //Can be used for any pathway db with unique accessionIDs
		Remark ?Text #Evidence
		Reference ?Paper XREF WBProcess

-----------
Required changes to other models: 

?Gene     WBProcess ?WBProcess XREF Gene #Evidence 
?Expression_cluster	 WBProcess ?WBProcess XREF Expression_cluster #Evidence 
?Interaction 	WBProcess ?WBProcess XREF Interaction
?Anatomy_term	WBProcess ?WBProcess XREF Anatomy_term
?Life_stage	WBProcess ?WBProcess XREF Life_stage 
?Molecule       WBProcess ?WBProcess XREF Molecule
?Phenotype	Associated_with WBProcess ?WBProcess XREF Phenotype 
?Picture        WBProcess ?WBProcess XREF Picture
?Movie          WBProcess ?WBProcess XREF ?Movie
?Paper	Refers_to  WBProcess ?WBProcess XREF Reference \\

-----------
Required changes to other models:
Ques. Is #Evidence needed in the changes below?

?Gene WBProcess ?WBProcess XREF Gene #Evidence
?Expression_cluster WBProcess ?WBProcess XREF Expression_cluster #Evidence
?Interaction WBProcess ?WBProcess XREF Interaction
?Anatomy_term WBProcess ?WBProcess XREF Anatomy_term
?Life_stage WBProcess ?WBProcess XREF Life_stage

?GO_term Associated_with WBProcess ?WBProcess XREF GO_term
?Phenotype Associated_with WBProcess ?WBProcess XREF Phenotype

?Picture WBProcess ?WBProcess XREF ?Picture
?Paper Refers_to WBProcess ?WBProcess XREF Reference
?Movie WBProcess ?WBProcess XREF ?Movie

Definition and use of tags

FielddescriptionOA field type
Tab 1
PGIDpostgres char line idAutogenerated
NameAn ID space for the process (e.g., WBpr:00001). For internal use onlyAutogenerated
Process_termPublic nameFree text
Other_nameSynonymsBig text
SummaryDefinition of the process with reference evidenceBig text
Related_processRelationships between different WB defined processesMulti-ontology list of WBProcesses (allow viewing by public name)
TaxonNCBITaxonomyIDMulti-ontology (NCBI Taxonomy)
Picture?Picture relevant to process ex. from reviewsMulti-list field from Picture
Movie?Movie relevant to process ex from ChrisMulti-list field from Movie
Pathwaylink to pathway database via a database accession numberFree text
RemarkA remark field to capture things that don't fit anywhere elseBig text
ReferencePapersMulti-ontology -Paper
CuratorCurating WBPersonList field -WBPerson
NOTESNO DUMP fieldBig text
TAB 2
Expression_clusterInvolved_entity for XREF ?Expression_cluster to WBProcessMulti-list Expression cluster list (needs to be generated from Wen's data on citace)
InteractionInvolved_entity for XREF ?Interaction to WBProcessMulti-list InteractionID list
AnatomyInvolved_entity for XREF Anatomy_term ?Anatomy_term to WBProcessMulti-ontology WBbt.obo
Life_stageInvolved_entity for XREF ?Life_stage to WBProcessMulti-ontology life stage.obo
GeneInvolved_entity for XREF to genes that have not yet been attached to genes and papers through any other tag (e.g., microarray cluster) or annotation. Direct gene annotations can be filtered out during .ace file dumps for those cases where the gene and paper have been connected to the process through other tags, e.g., anatomy.Multi-ontology Gene
GO_term(Associated_with) GO terms associated with the process: there will be no dedicated one-to-one mappingsMulti-ontology GO .obo
Phenotype_term(Associated_with) phenotypes relevant to the process: there will be no dedicated one-to-one mappingsMulti-ontology Phenotype.obo

----
.ace dump constraints: the following must be true

  • Unique WBProcessID
  • Unique Process name
  • Curator not blank
  • Process summary not blank

SAMPLE .ace

WBProcess : "WBbiopr:0000000"
Process_term "WormBase Biological Process"
Summary "Biological processes of the soil nematode based on experimental data in C. elegans, and related species. These processes in many ways will parallel GO biological process assignments; however these pages are aimed towards placing common knowledge about the worm and its studied biology in perspective with other biomedical fields. It is but one other tool to be used as a cross-field translator, along with Reactome, MetaCyc, and GO annotations." Person_evidence "WBPerson712"

WBProcess : "WBbiopr:0000001"
Process_term	 "Aging"
Other_name  "Life span determination"
Summary  "Changes occurring in a organism due to the breakdown of metabolic processes over the course of time. Extensive work on adult C. elegans animals has elucidated genes involved in the many processes involved in or affected by the decline of physical, metabolic, and behavioral aspects of an animal as it progresses over time beyond the developmental growth period." Paper_evidence "WBPaper00029019" 
Related_process	 "WBbiopr:0000002"
NCBITaxonomyID  "6239"
Gene	 "WBGene00000090" Paper_evidence "WBPaper00029019" //Karen
Gene	 "WBGene00000908" Paper_evidence "WBPaper00029019" //Karen
Gene	 "WBGene00000912" Paper_evidence "WBPaper00029019" //Karen
Gene	 "WBGene00000898" Paper_evidence "WBPaper00029019" //Karen
Gene	 "WBGene00001411" Paper_evidence "WBPaper00029019" //Karen
Gene	 "WBGene00001421" Paper_evidence "WBPaper00029019" //Karen 
Gene	 "WBGene00013973" Paper_evidence "WBPaper00029019" //Karen 
Gene	 "WBGene00002100" Paper_evidence "WBPaper00029019" //Karen 
Gene	 "WBGene00002090" Paper_evidence "WBPaper00029019" //Karen 
Gene	 "WBGene00004800" Paper_evidence "WBPaper00029019" //Karen
Gene	 "WBGene00004932" Paper_evidence "WBPaper00029019" //Karen
Expression_cluster "\[cgc5976\]:class_1" Paper_evidence "WBPaper00005976"
Expression_cluster "\[cgc5976\]:class_2" Paper_evidence "WBPaper00005976"
Expression_cluster "WBPaper00028789:pmk-1_downregulated" Paper_evidence "WBPaper00028789"
Expression_cluster "WBPaper00028789:pmk-1_upregulated" Paper_evidence "WBPaper00028789"
Expression_cluster "WBPaper00028789:PA14_vs_OP50_downregulated_4hr" Paper_evidence "WBPaper00028789"
Expression_cluster "WBPaper00028789:PA14_vs_OP50_downregulated_8hr" Paper_evidence "WBPaper00028789"
Expression_cluster "WBPaper00028789:PA14_vs_OP50_upregulated_4hr" Paper_evidence "WBPaper00028789"
Expression_cluster "WBPaper00028789:PA14_vs_OP50_upregulated_8hr" Paper_evidence "WBPaper00028789"
Expression_cluster "WBPaper00028789:PA14_vs_gacA_downregulated_4hr" Paper_evidence "WBPaper00028789"
Expression_cluster "WBPaper00028789:PA14_vs_gacA_downregulated_8hr" Paper_evidence "WBPaper00028789" 
Expression_cluster "WBPaper00028789:PA14_vs_gacA_upregulated_4hr" Paper_evidence "WBPaper00028789"
Expression_cluster "WBPaper00028789:PA14_vs_gacA_upregulated_8hr" Paper_evidence "WBPaper00028789"
Interaction "WBInteraction0004926" Paper_evidence "WBPaper00024278"
Interaction "WBInteraction0005204" Paper_evidence "WBPaper00024278"
Interaction "WBInteraction0005284" Paper_evidence "WBPaper00024278"
Interaction "WBInteraction0005582" Paper_evidence "WBPaper00024278"
Molecule "D020352" Paper_evidence "WBPaper00035248"
Phenotype	 "WBPhenotype:0000039"
Phenotype	 "WBPhenotype:0000061"
Phenotype	 "WBPhenotype:0001171"
Phenotype	 "WBPhenotype:0001775"
GO_term	"GO:0008340" //determination of adult lifespan
Reference "WBPaper00029019"
Reference "WBPaper00005896"
Reference "WBPaper00013462"
Reference "WBPaper00024278"
Reference "WBPaper00032062"
Reference "WBPaper00032165"

WBProcess "WBbiopr:0000002"
Process_term "Life span under dietary restriction"
Related_process "WBbiopr:0000001"
NCBITaxonomyID  "6239"

WBProcess "WBbiopr:0000027"
Process_term "Sensory response to touch"
Other_name "Mechanosensation" 
Summary	"Wild C. elegans and other nematodes live in dirt and eat bacteria, relying on mechanoreceptor neurons (MRNs) to detect collisions with soil particles and other animals as well as forces generated by their own movement. MRNs may also help animals detect bacterial food sources. Hermaphrodites and males have 22 putative MRNs; males have an additional 46 MRNs, most, if not all of which are needed for mating. This chapter reviews key aspects of C. elegans mechanosensation, including MRN anatomy, what is known about their contributions to behavior as well as the neural circuits linking MRNs to movement. Emerging models of the mechanisms used to convert mechanical energy into electrical signals are also discussed. Prospects for future research include expanding our understanding of the molecular basis of mechanotransduction and how activation of MRNs guides and modulates behavior." Paper_evidence "WBPaper00027280"
Reference "WBPaper00027280"

WBProcess "WBbiopr:0000003"
Process_term  "Autophagy"
Summary  "The degradation of cytoplasmic components via an autophagolysosome (autolysosome). Of the many types of autophagy in nature, macroautophagy, which involves the sequestration of cellular material by a double-membrane autophagosome, has been observed in C. elegans.  The steps in this degradation process include nucleation of vesicle formation, expansion of the membrane with concomitant capture of cellular components (vesicle elongation), autophagolysosome or autolysosome, formation (autophagosome fusion with lysosome), and completion (vesicle breakdown and the lysis of the captured cytoplasmic material) (WBPaper00031045). This is a general cellular process that is regulated and required during necrotic cell death." Paper_evidence "WBPaper00035143"
GO_term "GO:0000045"
GO_term "GO:0001845"
GO_term "GO:0006914"
GO_term "GO:0009986"
GO_term "GO:0010506"
GO_term "GO:0016236"
Gene	"WBGene00018294"  Paper_evidence "WBPaper00006070"
Gene 	"WBGene00010882"  Paper_evidence "WBPaper00006070"
Gene	"WBGene00002980"  Paper_evidence "WBPaper00006070"
Gene	"WBGene00006786"  Paper_evidence "WBPaper00006070"
Gene	"WBGene00000467"  Paper_evidence "WBPaper00023500"
Gene "WBGene00003954" Paper_evidence "WBPaper00028951"
Gene "WBGene00000898" Paper_evidence "WBPaper00030896"
Gene "WBGene00010130" Paper_evidence "WBPaper00030896" 
Gene "WBGene00006786" Paper_evidence "WBPaper00031045"
Gene "WBGene00002980" Paper_evidence "WBPaper00031045"
Gene "WBGene00006911" Paper_evidence "WBPaper00031045"
Gene "WBGene00006921" Paper_evidence "WBPaper00031045"
Gene "WBGene00006833" Paper_evidence "WBPaper00031470"
Gene "WBGene00003954" Paper_evidence "WBPaper00032500"
Related_process  "WBbiopr:0000036"

WBProcess "WBbiopr:0000015"
Process_term	"Locomotion"
Reference "WBPaper00035038" // "Forward locomotion of the nematode C. elegans is achieved through modulation of a single gait.

WBProcess "WBbiopr:0000028"
Process_term "Olfaction"
Other_name "Response to volatile cues"
Expression_cluster "WBPaper00024671:AFD_vs_AWB_downregulated" Paper_evidence "WBPaper00024671"
Expression_cluster "WBPaper00024671:AFD_AWB_vs_unsorted_downregulated" Paper_evidence "WBPaper00024671"
Expression_cluster "WBPaper00024671:AFD_AWB_vs_unsorted_upregulated" Paper_evidence "WBPaper00024671"
Expression_cluster "WBPaper00024671:AFD_vs_AWB_upregulated" Paper_evidence "WBPaper00024671"

WBProcess "WBbiopr:0000284"
Process_term	"Post-transcriptional RNA binding"
Summary	"\"The C. elegans genome encodes many RNA-binding proteins (RBPs) with diverse functions in development, indicative of extensive layers of post-transcriptional control of RNA metabolism. A number of C. elegans RBPs have been identified by forward or reverse genetics. They tend to display tissue-specific mutant phenotypes, which underscore their functional importance. In addition, several RBPs that bind regulatory sequences in the 3'' untranslated regions of mRNAs have been identified molecularly. Most C. elegans RBPs are conserved throughout evolution, suggesting that their study in C. elegans may uncover new conserved biological functions. In this review, we primarily discuss RBPs that are associated with well-characterized mutant phenotypes in the germ line, the early embryo, or in somatic tissues. We also discuss the identification of RNA targets of RBPs, which is an important first step to understand how an RBP controls C. elegans development. It is likely that most RBPs regulate multiple RNA targets. Once multiple RNA targets are identified, specific features that distinguish target from non-target RNAs and the type(s) of RNA metabolism that each RBP controls can be determined. Furthermore, one can determine whether the RBP regulates all targets by the same mechanism or different targets by distinct mechanisms. Such studies will provide insights into how RBPs exert coordinate control of their RNA targets, thereby affecting development in a concerted fashion.\"" Paper_evidence "WBPaper00027224" //RNA binding proteins
Gene	"WBGene00000105" 	Paper_evidence	"WBPaper00027224"//needs updating? 
Gene	"WBGene00000231" 	Paper_evidence	"WBPaper00027224"//needs updating? 
Gene	"WBGene00000770" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00000935" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00000939" 	Paper_evidence	"WBPaper00027224"//needs updating?
Gene	"WBGene00001340" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00001368" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00001401" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00001402" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00001413" 	Paper_evidence	"WBPaper00027224"//needs updating?
Gene	"WBGene00001481" 	Paper_evidence	"WBPaper00027224"//needs updating?
Gene	"WBGene00001484" 	Paper_evidence	"WBPaper00027224"//is gld-1?
Gene	"WBGene00001595" 	Paper_evidence	"WBPaper00027224"// query goes to a preview of fox-1,  what is this about?
Gene	"WBGene00001596" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00001597" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00001598" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00001601" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00001609" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00003014" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00003172" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00003221" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00003229" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00003230" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00003389" 	Paper_evidence	"WBPaper00027224"//needs updating?
Gene	"WBGene00003423" 	Paper_evidence	"WBPaper00027224"// no concise description
Gene	"WBGene00003783" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00003784" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00003785" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00003864" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00003912" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00003992" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00004027" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00004078" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00004093" 	Paper_evidence	"WBPaper00027224"//no concise description
Gene	"WBGene00004246" 	Paper_evidence	"WBPaper00027224"//needs updating?
Gene	"WBGene00004239" 	Paper_evidence	"WBPaper00027224"//no concise description
Gene	"WBGene00004244" 	Paper_evidence	"WBPaper00027224"//no concise description
Gene	"WBGene00004323" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00004326" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00004387" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00004855" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00004984" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00006605" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00006787" 	Paper_evidence	"WBPaper00027224"
Gene	"WBGene00006807" 	Paper_evidence	"WBPaper00027224"
Related_process	"WBbiopr:0000136" //Translational regulation

WBProcess "WBbiopr:0000016"
Process_term  "Response to pathogens"
Related_process	"WBbiopr:0000014" //Behavior

WBProcess "WBbiopr:0000017"
Process_term	"Foraging"
Related_process	"WBbiopr:0000015" //Locomotion
Related_process	"WBbiopr:0000018" //Feeding

WBProcess "WBbiopr:0000018"
Process_term	"Feeding"

WBProcess "WBbiopr:0000019"
Process_term  "Defecation"
Gene "WBGene00000895"  Paper_evidence "WBPaper00024671"

WBProcess "WBbiopr:0000020"
Process_term  "Egg laying"
Summary	"C. elegans hermaphrodites are self-fertile, and their rate and temporal pattern of egg-laying are modulated by diverse environmental cues. Egg-laying behavior has served as an important phenotypic assay for the   Genetic dissection of neuronal signal transduction mechanisms. This chapter reviews our current understanding of the neuronal and neurochemical mechanisms underlying the control of egg-laying in C. elegans. The roles of specific neurons in the egg-laying motor circuit, which release multiple neurotramsmitters affecting distinct parameters of egg-laying muscle activity, and the possible mechanisms for sensory control of egg-laying behavior, are discussed." Paper_evidence "WBPaper00027242" //Egg laying
Reference "WBPaper00027242" 
Reference "WBPaper00027242" 

WBProcess "WBbiopr:0000022"
Process_term	"Male mating"
Summary	"Caenorhabditis elegans male mating provides an excellent opportunity to determine how sensory perception regulates behavior and motor programs. The male-specific nervous system and muscles are superimposed over the   General nervous system and musculature.   Genetic screens and genomic approaches have identified male-specific and male-enriched   Genes as well as non-sex specific molecules specialized for mating sub-behaviors. In this chapter, we discuss the cellular,   Genetic, and molecular basis for male mating behavior." Paper_evidence "WBPaper00029029"// Male mating behavior  
Reference  "WBPaper00000762"
Reference  "WBPaper00029029"
Reference  "WBPaper00029029" 
Gene "WBGene00004041" Paper_evidence "WBPaper00032027"//uncloned
Phenotype  "WBPhenotype:0001414" //male_mating_defective
Phenotype  "WBPhenotype:0001729" // mating_plug_produced

WBProcess "WBbiopr:0000036"
Process_term	"Cell death"
Summary	"The death of a cell is a highly regulated process that occurs frequently throughout development. Current research shows that there are four different ways a cell can die, programmed cell death, necrosis, autophagy, and cytotoxic cell death.  Research in C. elegans  pioneered the discovery of the molecular pathway responsible for programmed cell death. More recent work using this model organism has made headways into elucidating the genes involved in regulating and impacting these other methods of cell death.  There is controversy as to whether or not cell death by autophagy has been observed in C. elegans animals; however, an aspect of autophagy, macroautophagy, has been reported." Paper_evidence "WBPaper00031045"
Summary	"The death of a cell is a highly regulated process that occurs frequently throughout development. Current research shows that there are four different ways a cell can die, programmed cell death, necrosis, autophagy, and cytotoxic cell death.  Research in C. elegans  pioneered the discovery of the molecular pathway responsible for programmed cell death. More recent work using this model organism has made headways into elucidating the genes involved in regulating and impacting these other methods of cell death.  There is controversy as to whether or not cell death by autophagy has been observed in C. elegans animals; however, an aspect of autophagy, macroautophagy, has been reported." Paper_evidence "WBPaper00031858"
Summary	"The death of a cell is a highly regulated process that occurs frequently throughout development. Current research shows that there are four different ways a cell can die, programmed cell death, necrosis, autophagy, and cytotoxic cell death.  Research in C. elegans  pioneered the discovery of the molecular pathway responsible for programmed cell death. More recent work using this model organism has made headways into elucidating the genes involved in regulating and impacting these other methods of cell death.  There is controversy as to whether or not cell death by autophagy has been observed in C. elegans animals; however, an aspect of autophagy, macroautophagy, has been reported." Paper_evidence "WBPaper00032500"
GO_term "GO:0012501" //GO biological process
Reference  "WBPaper00027291" //Programmed cell death
Reference  "WBPaper00028948"
Reference  "WBPaper00032172" // Germline survival and apoptosis
Reference  "WBPaper00035143" // Autophagy in C. elegans  

WBProcess "WBbiopr:0000037"
Process_term  "Programmed Cell Death"
Summary	"Programmed cell death is an integral component of C. elegans development.   Genetic studies in C. elegans have led to the identification of more than two dozen   Genes that are important for the specification of which cells should live or die, the activation of the suicide program, and the dismantling and removal of dying cells. Molecular and biochemical studies have revealed the underlying conserved mechanisms that control these three phases of programmed cell death. In particular, an interplay of transcriptional regulatory cascades and networks involving ces-1 , ces-2 , hlh-1 \/ hlh-2 , tra-1 , and other transcriptional regulators is crucial in activating the expression of the key death-inducing   Gene egl-1 in cells destined to die. A protein interaction cascade involving egl-1 , ced-9 , ced-4 and ced-3 results in the activation of the key cell death protease ced-3 . The activation of ced-3 initiates the cell disassembly process and nuclear DNA fragmentation, which is mediated by the release of apoptogenic mitochondrial factors ( cps-6 and wah-1 ) and which involves multiple endo- and exo-nucleases such as nuc-1 and seven CRN nucleases. The recognition and removal of the dying cell is mediated by two partially redundant signaling pathways involving ced-1 , ced-6 and ced-7 in one pathway and ced-2 , ced-5 , ced-10 , ced-12 and psr-1 in the other pathway. Further studies of programmed cell death in C. elegans will continue to advance our understanding of how programmed cell death is regulated, activated, and executed in multicellular organisms." Paper_evidence "WBPaper00027291"// Programmed cell death
Reference  "WBPaper00027291"
Related_process	"WBbiopr:0000036" //Cell death

WBProcess "WBbiopr:0000044"
Process_term  "Corpse engulfment"
Reference  "WBPaper00001438"
Gene "WBGene00000415" Paper_evidence "WBPaper00004503"
Reference "WBPaper00004716"
Reference "WBPaper00004897"
Reference "WBPaper00004899"
Reference "WBPaper00005200"
Related_process	"WBbiopr:0000036" //Cell death

WBProcess "WBbiopr:0000045"
Process_term "Corpse engulfment pathway I"
Related_process	"WBbiopr:0000044" //Corpse engulfment

WBProcess "WBbiopr:0000046"
Process_term "Corpse engulfment pathway II"
Related_process	"WBbiopr:0000044" //Corpse engulfment

WBProcess "WBbiopr:0000047"
Process_term "Cell division"
Summary	"A metazoan cell division cycle starts with DNA condensation and continues to the completion of cytokinesis, and the creation of an independent daughter cell.  In C. elegans, mitotic cell divisions are rapid, taking approx. 14 minutes, and follow a stereotypical pattern that are invariant from animal to animal during the first few divisions. Extensive research of cell division in C. elegans has elucidated many genes involved in the genetic and molecular pathways that occur during cell division in this metazoan animal, especially during these invariant stages of development. These studies demonstrate a role for these genes in one or many steps of cell division such as in nuclear envelope assembly\/ disassembly, centrosome dynamics, formation of the mitotic spindle, kinetochore assembly, chromosome segregation, and cytokinesis." Paper_evidence "WBPaper00027235"// Cell division
GO_term  "GO:0000281"
GO_term  "GO:00007077"
GO_term  "GO:00007084"
GO_term  "GO:0000910"
GO_term  "GO:0000915"
GO_term  "GO:0007108"
GO_term  "GO:0007109"
GO_term  "GO:0007110"
GO_term  "GO:0018985"
GO_term  "GO:0050181"
GO_term  "GO:0051301"// Cell division
GO_term  "GO:0051302"
GO_term  "GO:0051781"
GO_term  "GO:0055057"
Reference "WBPaper00027235"
Reference "WBPaper00027235"
Reference "WBPaper00029190"
Reference "WBPaper00029334"
Phenotype  "WBPhenotype:0001018"
Phenotype  "WBPhenotype:0001143"

WBProcess "WBbiopr:0000048"
Process_term "First mitotic cell division"
Summary	"This first division occurs after fertilization and results in an asymmetric first cleavage. This is a very well-studied step in C. elegans development, which involves a number of well-defined biological steps." Person_evidence "WBPerson712"
Database "WikiPathays" "WP1411"
Reference "WBPaper00027235" //Cell division
Reference "WBPaper00004846"

WBProcess "WBbiopr:0000058"
Process_term "Anaphase"
Reference "WBPaper00024319"
Reference "WBPaper00004513"
Reference "WBPaper00004846"
Reference "WBPaper00024503"
Related_process	"WBbiopr:0000047" //Cell division

Updated