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BUGSModelLibrary is a prototype PKPD model library for use with WinBUGS 1.4.3

The current version includes:

  • Specific linear compartmental models:
    • One compartment model with first order absorption
    • Two compartment model with elimination from and first order absorption into central compartment
  • General linear compartmental model described by a matrix exponential
  • General compartmental model described by a system of first order ODEs

The models and data format are based on NONMEM/NMTRAN/PREDPP conventions including:

  • Recursive calculation of model predictions
    • This permits piecewise constant covariate values
  • Bolus or constant rate inputs into any compartment
  • Handles single dose, multiple dose and steady-state dosing histories
  • Implemented NMTRAN data items include:
    • TIME, EVID, CMT, AMT, RATE, ADDL, II, SS

The library provides BUGS language functions that calculate amounts in each compartment. BUGSModelLibrary is an active, open-source project of Metrum Research Group (http://www.metrumrg.com).

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