PyGTK is known to be incompatible with PyPy. There are build issues likely to be shared with other C extensions, namely that the autoconf/automake macro used to find header files doesn't work with PyPy. Aside from that, other incompatibilities remain that prevent a successful build.
PyGTK (including PyGObject and PyCairo) is a dependency for many applications:
|Category:||GUI library bindings|