There are beta's for macOS 10.12, which means it is time to look at the SDK bindings for that version of OSX.
I'm working my way through the textual diffs between the last SDK I looked at and the headers included with Xcode 8 beta 2.
There's currently 12 frameworks that I haven't looked at at all, 5 that need more work and about 21 that aren't available from PyObjC at all (even with the 10.11 SDK).
The 12 SDKs I haven't look at are the 12 with the largest textual diff and includes some of the low-level SDKs that have required lots of manual updating in the past (such as CoreFoundation)
For the other frameworks I have updated the metadata, but I haven't run tests on a 10.12 machine. All updates are currently local on my machine and not in the repository.