Currently, I am following a couple of shows that are being released in both 10-bit and 8-bit versions. Shana Project's present item titles only say, e.g., "Shingeki no Kyojin - 1 HD [Hatsuyuki-Kaitou]", which means that if I want automatic downloads both 8- and 10-bit files get dumped into the same folder.
If the SP feed items would say e.g. "Shingeki no Kyojin - 1 HD 10bit [Hatsuyuki-Kaitou]" then I could create two filters, one including the "10bit" flag and one without (specifying "Not: 10bit"), and auto-download the files to separate folders.
Having separate folders is useful for things like playing anime with MALUpdater, which can get confused and play different bit depth files while watching a sequence of episodes.