<!-- Basic WP loop -->
<?php if ( have_posts() ) : while ( have_posts() ) : the_post(); ?>
<!-- Do what ever you want here -->
<?php endwhile; endif; ?>

<!-- WP Query for the recent posts -->
<?php $recentpost = new WP_Query("showposts=6"); while($recentpost->have_posts()) : $recentpost->the_post(); ?>
<!-- Do what ever you want here -->
<?php endwhile; ?>

<!-- WP Query for the recent custom posts (in this example the type is portfolio) -->
<?php $recentPortfolio = new WP_Query( 'post_type=portfolio&posts_per_page=-1' ); while ($recentPortfolio->have_posts()) : $recentPortfolio->the_post(); ?>
<!-- Do what ever you want here -->
<?php endwhile; ?>