If you are asking about Django's query syntax, then yes it is possible.
With django-easyfilters, currently it's not possible to do this kind of filtering. I haven't yet thought about how difficult it would be add this. Note that there are two different cases - the ForeignKey case and the ManyToMany case.
Apologies for bumping this old thread, but I am very curious to see what came out of here. Hoping to use easyfilters to filter on users, but all relations are reversed. So I have Skills, which have a ForeignKey to User, but I would like to filter on Users.
It sounds like you are looking for some kind of 'Reverse ForeignKey' filter, which is a bit different from what this ticket is about. Given that I've already done M2M, which is just as complex as reverse foreign key, this should be possible. I don't know when I will have the time to implement it though.