Upon installation, Flake8 enables a setuptools command that checks Python files declared by your project.
Running python setup.py flake8 on the command line will check the files listed in your py_modules and packages. If any warning is found, the command will exit with an error code:
$ python setup.py flake8
Also, to allow users to be able to use the command without having to install flake8 themselves, add flake8 to the setup_requires of your setup() like so:
setup( name="project", packages=["project"], setup_requires=[ "flake8" ] )