using DocumentFormat.OpenXml.Packaging;
using DocumentFormat.OpenXml.Spreadsheet;

 class Program
    {
        static void Main(string[] args)
        {
            string docName = "Delete text from a cell.xlsx";
            string sheetName = "Sheet4";
            string colName = "B";
            uint rowIndex = 2;
            DeleteTextFromCell(docName, sheetName, colName, rowIndex);
        }
        // Given a document, a worksheet name, a column name, and a one-based row index,
        // deletes the text from the cell at the specified column and row on the specified worksheet.
        public static void DeleteTextFromCell(string docName, string sheetName, string colName, uint rowIndex)
        {
            // Open the document for editing.
            using (SpreadsheetDocument document = SpreadsheetDocument.Open(docName, true))
            {
                IEnumerable<Sheet> sheets = document.WorkbookPart.Workbook.GetFirstChild<Sheets>().Elements<Sheet>().Where(s => s.Name == sheetName);
                if (sheets.Count() == 0)
                {
                    // The specified worksheet does not exist.
                    return;
                }
                string relationshipId = sheets.First().Id.Value;
                WorksheetPart worksheetPart = (WorksheetPart)document.WorkbookPart.GetPartById(relationshipId);

                // Get the cell at the specified column and row.
                Cell cell = GetSpreadsheetCell(worksheetPart.Worksheet, colName, rowIndex);
                if (cell == null)
                {
                    // The specified cell does not exist.
                    return;
                }

                cell.Remove();
                worksheetPart.Worksheet.Save();
            }
        }

        // Given a worksheet, a column name, and a row index, gets the cell at the specified column and row.
        private static Cell GetSpreadsheetCell(Worksheet worksheet, string columnName, uint rowIndex)
        {
            IEnumerable<Row> rows = worksheet.GetFirstChild<SheetData>().Elements<Row>().Where(r => r.RowIndex == rowIndex);
            if (rows.Count() == 0)
            {
                // A cell does not exist at the specified row.
                return null;
            }

            IEnumerable<Cell> cells = rows.First().Elements<Cell>().Where(c => string.Compare(c.CellReference.Value, columnName + rowIndex, true) == 0);
            if (cells.Count() == 0)
            {
                // A cell does not exist at the specified column, in the specified row.
                return null;
            }

            return cells.First();
        }

        // Given a shared string ID and a SpreadsheetDocument, verifies that other cells in the document no longer 
        // reference the specified SharedStringItem and removes the item.
        private static void RemoveSharedStringItem(int shareStringId, SpreadsheetDocument document)
        {
            bool remove = true;

            foreach (var part in document.WorkbookPart.GetPartsOfType<WorksheetPart>())
            {
                Worksheet worksheet = part.Worksheet;
                foreach (var cell in worksheet.GetFirstChild<SheetData>().Descendants<Cell>())
                {
                    // Verify if other cells in the document reference the item.
                    if (cell.DataType != null &&
                        cell.DataType.Value == CellValues.SharedString &&
                        cell.CellValue.Text == shareStringId.ToString())
                    {
                        // Other cells in the document still reference the item. Do not remove the item.
                        remove = false;
                        break;
                    }
                }

                if (!remove)
                {
                    break;
                }
            }

            // Other cells in the document do not reference the item. Remove the item.
            if (remove)
            {
                SharedStringTablePart shareStringTablePart = document.WorkbookPart.SharedStringTablePart;
                if (shareStringTablePart == null)
                {
                    return;
                }

                SharedStringItem item = shareStringTablePart.SharedStringTable.Elements<SharedStringItem>().ElementAt(shareStringId);
                if (item != null)
                {
                    item.Remove();

                    // Refresh all the shared string references.
                    foreach (var part in document.WorkbookPart.GetPartsOfType<WorksheetPart>())
                    {
                        Worksheet worksheet = part.Worksheet;
                        foreach (var cell in worksheet.GetFirstChild<SheetData>().Descendants<Cell>())
                        {
                            if (cell.DataType != null &&
                                cell.DataType.Value == CellValues.SharedString)
                            {
                                int itemIndex = int.Parse(cell.CellValue.Text);
                                if (itemIndex > shareStringId)
                                {
                                    cell.CellValue.Text = (itemIndex - 1).ToString();
                                }
                            }
                        }
                        worksheet.Save();
                    }

                    document.WorkbookPart.SharedStringTablePart.SharedStringTable.Save();
                }
            }
        }
    }

using Aspose.Cells;

static void Main(string[] args)
        {
            string docName = "Delete text from a cell.xlsx";
            string sheetName = "Sheet4";
            string colName = "B";
            uint rowIndex = 2;
            DeleteTextFromCell(docName, sheetName, colName, rowIndex);
        }

        private static void DeleteTextFromCell(string docName, string sheetName, string colName, uint rowIndex)
        {
            //Instantiating a Workbook object
            Workbook workbook = new Workbook(docName);

            //Obtaining the reference of the worksheet by passing its Name
            Worksheet worksheet = workbook.Worksheets[sheetName];

            //Removing value from cell
            worksheet.Cells[colName + rowIndex].PutValue("");

            //Saving the Excel file
            workbook.Save(docName);
        }