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BUGSModelLibrary is a prototype PKPD model library for use with WinBUGS 1.4.3
The current version includes:
- Specific linear compartmental models:
- One compartment model with first order absorption
- Two compartment model with elimination from and first order absorption into central compartment
- General linear compartmental model described by a matrix exponential
- General compartmental model described by a system of first order ODEs
The models and data format are based on NONMEM/NMTRAN/PREDPP conventions including:
- Recursive calculation of model predictions
- This permits piecewise constant covariate values
- Bolus or constant rate inputs into any compartment
- Handles single dose, multiple dose and steady-state dosing histories
- Implemented NMTRAN data items include:
- TIME, EVID, CMT, AMT, RATE, ADDL, II, SS
The library provides BUGS language functions that calculate amounts in each compartment. BUGSModelLibrary is an active, open-source project of Metrum Research Group (http://www.metrumrg.com).
Downloads
- BUGSModelLibraryUserManual.pdf: BUGSModelLibrary 1.2 documentation
- BUGSModelLibrary.zip: BUGSModelLibrary 1.2 installation package
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